University of Technology Sydney

91560 Tissue Engineering Scaffolds

Warning: The information on this page is indicative. The subject outline for a particular session, location and mode of offering is the authoritative source of all information about the subject for that offering. Required texts, recommended texts and references in particular are likely to change. Students will be provided with a subject outline once they enrol in the subject.

Subject handbook information prior to 2020 is available in the Archives.

UTS: Science: Life Sciences
Credit points: 6 cp
Result type: Grade and marks

There are course requisites for this subject. See access conditions.

Description

Tissue engineering is a radical new concept for the treatment of disease and injury. It involves the use of the technologies of molecular and cell biology, combined with those of advanced materials science and processing, in order to produce tissue regeneration. This subject outlines concepts underlying the development of biomaterial scaffolds and tissue engineering-based products, and aims to give students a theoretical and practical understanding of the tools available for developing such 'systems' as well as the biological, physical and chemical constraints of these systems.

This subject provides an introduction to the characterisation, analysis and design of biomaterials for the purposes of correcting deformities, restoring lost function or promoting tissue regeneration in the human body. The principles of materials science, specifically the fundamental structure–function relationships of biomaterials, are explored in relation to the use of materials in the body. The subject also examines properties of biomaterials as they relate to minimising corrosion, controlling degradation and tailoring cell–material interaction to guide cell growth and tissue regeneration. Topics include structural properties of materials, characterisation of materials, tissue responses to implants and designing materials for tissue engineering.

Laboratory classes are used to allow students to gain practical experience with computer-aided design software to design different scaffold materials and be involved in their 3D printing characterisation.

Subject learning objectives (SLOs)

Course intended learning outcomes (CILOs)

This subject also contributes specifically to the development of following course intended learning outcomes:

  • Evaluate: Combine advanced application of in- depth and up-to-date technical knowledge and research principles in forensic science, critically evaluating the information source and relevance, with a focus on evidence, investigative and intelligence frameworks relevant to professional practice. (1.3)
  • Synthesise: Tackle the challenge of real-world forensic science problems by investigating, analyzing and critically evaluating different solutions to complex problems. (2.2)
  • Evaluate: Assess, argue for, and conduct appropriate approaches to independent research adopting techniques from a variety of sources in the context of relevant professional practice. (2.3)
  • Analyse: Engage in work practices that demonstrate an understanding of health and safety requirements, ethical conduct, risk management, and organisation and collaborative skills, record keeping in the context of forensic science. (3.1)
  • Synthesise: Develop and prepare ethical solutions to global forensic science problems that can impact on society. (3.2)

Contribution to the development of graduate attributes

1. Disciplinary knowledge and its appropriate application.

You will develop theoretical knowledge of tissue engineering scaffolds and the theory and professional practice involved with biomaterial scaffold production.

2. An enquiry-oriented approach.

a) You will have the opportunity to apply critical and independent thinking to the planning of experiments using a wide range of methods to generate relevant data answering a specific scientific question. You will also learn how to find and interpret theoretical knowledge and practiced methodologies from a wide range of sources, such as published literature, online databases and the course content, applying an understanding of recent developments in the discipline.

b) You will have the opportunity to learn to use different sources and types of information to interpret experimental data and contextualise it in the broader scope of the field, adding depth and significance to data analysis through the use of peer-reviewed publications, databases, research and review articles, textbooks, catalogues and technical reference books.

3. Professional skills and their appropriate application.

a) You will have an opportunity to develop professional level competency in advance hands-on biomaterial production methods and data analysis.

b) You will have an opportunity to develop technical and creative skills to investigate, analyse and synthesise complex information, problems, concepts and theories and to apply established theories to different bodies of knowledge or practice to integrate physico-chemical data within the scope of broader systems biology and medical research programs.

c) You will have an opportunity to refine skills in the management of the work-load required for scientific based practice and professional work. Time management will be developed through strictly time-limited practical and workshop sessions.

4. Ability and motivation for continued intellectual development

a) You will have an opportunity to reflect and learn from your experience and to incorporate those skills in a practical setting.

b) You will have an opportunity to seek out information on current and future trends in tissue engineering scaffolds and make judgement on the development of scaffold materials.

5. Engagement with the needs of Society

a) You will have an opportunity to learn skills that will signfiicantly impact the needs of current and future society.

b) You will have an opportunity to be expose to the ethics and regulatory awareness of current and future challenges of engineering tissue scaffolds for personalized medical implants.

6. Communication skills.

You will have the opportunity to develop fundamental scientific presentation skills, both written and oral. Projects and exercises are designed to allow you to gain competence and confidence in scientific reporting to professional audiences including graphical literacy and journal report writing.

7. Initiative and innovative ability

You will have an opportunity to self-assess your skills and to think about ways to improve and refine your own techniques and to apply these scientific skills in different scenarios and applications. You will be required to develop a sense of self-risk assesment and to make inform judgement on taking risks.

Teaching and learning strategies

The content of the subject will be delivered using both face-to-face and online modes. Short online videos will be available for you to view prior to the relevant workshop or practical class. In workshop and practical classes, this online content will be reinforced and elaborated on using a series of examples and case studies based upon current research in the field.Throughout the session, students will have 30 hours of face-to-face lectures, seminars and practical work. This practically orientated subject provides hands-on experience in the design, fabrication and characterization of biomaterials for medical applications. You will use synthetic and natural materials to fabricate a scaffold for applications such as tissue engineering, wound healing or controlled drug delivery. A challenge-based laboratory project will be assigned which will require students to design a biomaterial scaffold that meets specific design criteria, and quantitatively assess the properties of this scaffold to evaluate how well the criteria were satisfied. Design criteria may include physico-chemical characterization, mechanical strength, biocompatibility, porosity, degradation rate and/or release kinetics. You will complete the project collaboratively in teams and communicate their findings in both written and oral modes.

Assessment

Assessment task 1: Project 3D Design and Printing

Intent:

This assessent task contibutes to the development of the following graduate attributes:

1. Disciplinary knowledge and its appropriate application

2. An Enquiry-oriented approach

3. Professional skills and their appropriate application

5. Engagement with the needs of Society

7. Initiative and innovative ability

Objective(s):

This assessment task addresses subject learning objective(s):

4, 5 and 6

This assessment task contributes to the development of course intended learning outcome(s):

.0, .0, 2.2, 2.3 and 3.1

Type: Project
Groupwork: Individual
Weight: 35%
Length:

1 CAD file and 1 printed sample

Criteria:

The project will assess your ability to use the 3D rendering software to operate and design an appropriate medical scaffold that can be translated into a 3D printed design. You will be assessed on your ability to optimize designs and provide the engineering properties of medical scaffolds. You will submit a final report detailing your rationale for the design and critically assess your design for future improvements.

The report will be assessed on your ability to produce a document satisfying the prescribed criteria with the aim of allowing you to practice professional scientific writing (application of a professional skill).

Assessment task 2: Cell Culture Techniques

Intent:

This assessent task contibutes to the development of the following graduate attributes:

1. Disciplinary knowledge and its appropriate application

2. An Enquiry-oriented approach

3. Professional skills and their appropriate application

Objective(s):

This assessment task addresses subject learning objective(s):

1, 2 and 6

This assessment task contributes to the development of course intended learning outcome(s):

.0, 2.2 and 2.3

Type: Laboratory/practical
Groupwork: Individual
Weight: 35%
Length:

Self-critical reports (max 500 words)

Criteria:

You will be assessed based on your individual ability to demonstrate technical skills to perform basic cell culture technique including changing medium and resuspending cells. You will also be assessed on your ability to communicate and organize results clearly to a specialised scientific audience.

Assessment task 3: Practical class datasheets

Intent:

This assessent task contibutes to the development of the following graduate attributes:

1. Disciplinary knowledge and its appropriate application

2. An Enquiry-oriented approach

3. Professional skills and their appropriate application

4. Ability to be a lifelong learner

6. Communication skills

Objective(s):

This assessment task addresses subject learning objective(s):

1, 2, 3 and 4

This assessment task contributes to the development of course intended learning outcome(s):

.0, 1.3, 2.2, 2.3 and 3.2

Type: Laboratory/practical
Groupwork: Individual
Weight: 15%
Length:

Complete all questions in report

Criteria:

You will be assessed on your ability to operate scientific equipment and on the accuracy of your results. You will be assessed on your accuracy of interpretation of results and ability to apply the results to answer the prescribed questions.

Assessment task 4: Individual Report

Intent:

This assessent task contibutes to the development of the following graduate attributes:

1. Disciplinary knowledge and its appropriate application

2. An Enquiry-oriented approach

3. Professional skills and their appropriate application

5. Engagement with the needs of Society

6. Communication skills

Objective(s):

This assessment task addresses subject learning objective(s):

2, 4 and 6

This assessment task contributes to the development of course intended learning outcome(s):

.0, 1.3, 2.2, 2.3 and 3.1

Type: Report
Groupwork: Individual
Weight: 15%
Length:

1500-2000 words

Criteria:

You will be assessed on your ability to apply the knowledge gained throughout the subject by the level of detail and accuracy of the methodology approach towards the evaluation of biomaterial scaffolds.

References

Hutmacher DW, Scaffolds in tissue engineering bone and cartilage http://dx.doi.org/10.1016/S0142-9612(00)00121-6