University of Technology Sydney

65004 Medicinal Chemistry Honours 2

Warning: The information on this page is indicative. The subject outline for a particular session, location and mode of offering is the authoritative source of all information about the subject for that offering. Required texts, recommended texts and references in particular are likely to change. Students will be provided with a subject outline once they enrol in the subject.

Subject handbook information prior to 2020 is available in the Archives.

UTS: Science: Mathematical and Physical Sciences
Credit points: 24 cp
Result type: Grade and marks

There are course requisites for this subject. See access conditions.

Description

Scientific research brings together the scientific method, knowledge, observations, and sound data in order to answer specific questions. This can lead to a deeper understanding of a research question or the development of novel solutions to problems. The honours program is designed to enhance students' ability to develop professional research skills as they undertake a research project as part of a larger research endeavour within the Faculty of Science. The research project can only be conducted following approval into the course by the honours committee and prior negotiation on the part of the student with a member within the Faculty of Science regarding supervision and selection of a suitable research topic.

Subject learning objectives (SLOs)

Upon successful completion of this subject students should be able to:

1. Develop and execute a project plan with your supervisor, within the field of your research area
2. Establish effective channels of communication with your supervisor(s) and colleagues
3. Apply knowledge and skills into professional scientific practice and gain new expertise
4. Utilise appropriate methods of critical analysis to analyse scientific data sets
5. Assess your current skills, abilities and problem solving strategies to discover how to learn through experience
6. Communicate the findings of your research through both written and oral communication, including the contribution of the research to the scientific field

Course intended learning outcomes (CILOs)

This subject also contributes specifically to the development of following course intended learning outcomes:

  • Apply: Develop and distinguish between experimental skills using established and emerging medicinal chemistry techniques. (1.1)
  • Analyse: Examine and combine knowledge of medicinal chemistry as well as relevant areas in chemistry, biology, and pharmacology. (1.2)
  • Synthesise: Integrate extensive knowledge of the principles of medicinal chemistry to drug design and development. (1.3)
  • Apply: Identify, scope, and investigate problems and make complex logical deductions from evidence. (2.1)
  • Analyse: Discover, gather, and critically evaluate data and academic sources. (2.2)
  • Synthesise: Design complex experiments using medicinal chemistry strategies. (2.3)
  • Apply: Act safely and responsibly in laboratory and practical settings. (3.1)
  • Analyse: Organise and manage a major project using time management and collaborative skills. (3.2)
  • Synthesise: Develop advanced technical skills for effective and ethical contributions to society. (3.3)
  • Apply: Demonstrate well-developed individual and independent learning strategies enabled by peer review and self-reflection. (4.1)
  • Analyse: Discover new information acquired through experimentation to formulate hypotheses. (4.2)
  • Synthesise: Adapt critical thinking skills to develop creative solutions for contemporary medicinal chemistry problems. (4.3)
  • Apply: Demonstrate advanced speaking skills to communicate scientific discovery effectively to peers and other scientific audiences. (5.1)
  • Analyse: Exhibit high-quality writing skills to present a clear and coherent exposition of knowledge and ideas to a variety of audiences. (5.2)
  • Synthesise: Extend professional interpersonal communication skills to both peers and teaching staff. (5.3)

Contribution to the development of graduate attributes

The Faculty of Science lists six graduate attributes that you will develop during your course at UTS. This subject has the potential link to all UTS graduate attributes, however since each research project will be different, the specific tasks and roles of each student will be different and as such the depth of linkage to any attribute will differ.

Graduate attribute 1 - Disciplinary knowledge
An understanding of the nature, practice & application of the chosen science discipline will be instilled in students through their research projects. Student will deepen their understanding of their chosen field through the reading of scientific research articles and application of practical skills in the laboratory.

Graduate attribute 2 - Research, inquiry and critical thinking
Students will gain a thorough understanding of how the scientific method is used for the development of a research plan to investigate a topic of interest and in knowledge acquisition. This will encompass the development of a research plan, gathering of data and then utilisation of problem solving and critical thinking to analyse the data to gain a new understanding of their research question.

Graduate attribute 3 - Professional, ethical and social responsibility
Students will acquire, develop, employ, and integrate a range of technical, practical and professional skills, and apply them in a research project context, ensuring they work in appropriate and ethical ways. Students will develop their ability to work autonomously and collaboratively in a research lab, which will allow the development of numerous skills as a professional research scientist, including time management skills, personal organisation skills, teamwork skills, computing skills, laboratory skills, data handling, quantitative and graphical literacy skills. Students will gain an awareness of the role of science within a global culture and willingness to contribute actively to the shaping of community views on complex issues where the methods and findings of science are relevant. This will be demonstrated in their ability to explain the relevance and significance of their project to the global community.

Graduate attribute 4 - Reflection, innovation and creativity
Learning beyond formal educational contexts, that is based on the ability to make effective judgments about one’s own work. Students will have the opportunity to engage in self-reflection in order to improve research approaches throughout the project. In additional, students have the capacity to learn in, and from, new related disciplines to enhance the application of scientific knowledge and skills in professional contexts.

Graduate attribute 5 - Communication
Students will further develop of the different forms of communication - writing, reading, speaking, listening - including visual and graphical, relevant to a career in science and scientific communication. You will also learn how to appropriately communicate with other scientists and professionals within the industry, and communicate scientific data effectively for different audiences.

Teaching and learning strategies

This subject is a project-based subject; therefore, the learning will be experiential and hands-on within a research laboratory setting, with guidance provided by the project supervisor and their research team. Students will be actively involved in the planning of their project from the beginning of the teaching session and working collaboratively with the project supervisor and their research team. Students will develop skills as a professional research scientist that includes working collaboratively with other scientists towards research goals.

Students will receive regular formative feedback on their understanding of the project and their practical skills from their supervisor and research team in the laboratory. Students have the opportunity to seek feedback from their project supervisor on different aspects of the research project and prior to submitting the assessment tasks.

Content (topics)

You will learn broadly the following topics:

  • The development, enhancement and application of professional scientific skills in the area of your chosen discipline
  • Aptitude and knowledge in generic skills associated with successful management of a scientific project
  • Critical analysis of scientific data sets
  • Scientific communication to a wide variety of audiences
  • The skills of reflection, self-assessment and the ability to learn independently

Assessment

Assessment task 1: Coursework

Intent:

This assessment task addresses the following graduate attributes:

  1. Disciplinary knowledge
  2. Research, inquiry and critical thinking
  3. Professional, ethical and social responsibility
  4. Reflection, innovation and creativity
  5. Communication
Objective(s):

This assessment task addresses subject learning objective(s):

2, 4 and 6

This assessment task contributes to the development of course intended learning outcome(s):

1.2, 1.3, 2.1, 2.2, 3.3, 4.1, 4.3, 5.1 and 5.2

Type: Exercises
Groupwork: Individual
Weight: 25%
Criteria:

A series of assignments will be assessed using rubrics available on UTSOnline.

Assessment task 2: Final seminar

Intent:

This assessment task addresses the following graduate attributes:

  1. Disciplinary knowledge
  2. Research, inquiry and critical thinking
  3. Professional, ethical and social responsibility
  4. Reflection, innovation and creativity
  5. Communication
Objective(s):

This assessment task addresses subject learning objective(s):

1, 2, 3, 4, 5 and 6

This assessment task contributes to the development of course intended learning outcome(s):

1.3, 2.1, 2.2, 2.3, 3.1, 3.2, 3.3, 4.2, 4.3 and 5.3

Type: Presentation
Groupwork: Individual
Weight: 10%
Criteria:

The criteria you will be assessed on are;

  • Ability to work with a minimum of supervision
  • Capability and confidence in the laboratory
  • Good professional traits (independence, collaborative learning)
  • Development of problem-solving skills
  • An ability to overcome project issues by researching and trying new ideas
  • Demonstrated knowledge of your area of research
  • A deeper comprehension of the discipline and specific research field
  • Clear articulation, application and synthesis of disciplinary knowledge

Assessment task 3: Thesis

Intent:

This assessment task addresses the following graduate attributes:

  1. Disciplinary knowledge
  2. Research, inquiry and critical thinking
  3. Professional, ethical and social responsibility
  4. Reflection, innovation and creativity
  5. Communication
Objective(s):

This assessment task addresses subject learning objective(s):

1, 2, 3, 4, 5 and 6

This assessment task contributes to the development of course intended learning outcome(s):

1.1, 1.2, 1.3, 2.1, 2.2, 2.3, 3.2, 3.3, 4.1, 4.2, 4.3, 5.2 and 5.3

Type: Thesis
Groupwork: Individual
Weight: 65%
Criteria:

The criteria you are assessed on are;

  • Literature review and introduction
    • Comprehensive, critical review of the current research
    • Aims and objectives are clearly stated and are reflected in the content
  • Experimental methods
    • Layout of methods in a discipline appropriate manner with enough detail for reproduction
    • Evidence of an experimental design process that was used to develop or refine the experimental methods undertaken
  • Results
    • Clearly presented and explained
    • Appropriate data treatment or analysis methods (where applicable) with justification of this choice
    • The data are sound, of high quality and contribute original knowledge to the area
  • Discussion
    • Clear and critical evaluation of results and data analysis
    • Ability to draw inferences and relate data to hypotheses
    • Synthesis of knowledge by discussion of results in the context of existing literature
    • Outline of significance of research to the discipline
  • Conclusions
    • Address of the main aims and objectives of the project and provision of an honest reflection of the results and discussion chapters
    • Demonstration of critical thinking skills by suggesting future research directions based on the work contained in the thesis
  • Written communication
    • Clear writing and structure with a logical flow
    • The language, style, formatting and referencing style are appropriate for written scientific work
    • Typographical and grammatical errors are kept to a minimum

Minimum requirements

The Honours grade will be determined using the following weighting:

  • Coursework 25%
  • Final Seminar 10%
  • Thesis 65%

Coursework was completed in subject 65003 Medicinal Chemistry (Honours) 1 carried out in the previous semester. The same mark is submitted for both subjects as the assessment tasks are finalised during Medicinal Chemistry (Honours) 2.

In order to pass this subject, students must receive at least 50% of the marks available.