University of Technology Sydney

65002 Advanced Medicinal Chemistry

Warning: The information on this page is indicative. The subject outline for a particular session, location and mode of offering is the authoritative source of all information about the subject for that offering. Required texts, recommended texts and references in particular are likely to change. Students will be provided with a subject outline once they enrol in the subject.

Subject handbook information prior to 2020 is available in the Archives.

UTS: Science: Mathematical and Physical Sciences
Credit points: 6 cp
Result type: Grade and marks

There are course requisites for this subject. See access conditions.

Description

This subject is designed to introduce the different skills required to be a successful scientific researcher. The subject explores the skills needed to be an effective researcher during the Honours year of the degree, and after its completion. Students learn to write a journal article using ACS conventions. Students create a presentation on their Honours project topic which is then delivered in a symposium organised by their peers. Students learn how to search patents and compile a report for an employer on a specified medicinal product. Students attend facilitated workshops that develop their skills to become effective researchers, and then submit assignments using these developed skills.

Subject learning objectives (SLOs)

Upon successful completion of this subject students should be able to:

1. Effectively search for patents and collate relevant information into a cohesive report
2. Work in a laboratory in an informed manner promoting best practice, and recognise appropriate behaviour of themselves and those around them
3. Develop written and oral communication skills to convey scientific information to a diverse audience
4. Use skills to organise and facilitate a symposium of presentations
5. Adhere to specified guidelines for presentation and formatting of work submitted as a journal article

Course intended learning outcomes (CILOs)

This subject also contributes specifically to the development of following course intended learning outcomes:

  • Analyse: Examine and combine knowledge of medicinal chemistry as well as relevant areas in chemistry, biology, and pharmacology. (1.2)
  • Synthesise: Integrate extensive knowledge of the principles of medicinal chemistry to drug design and development. (1.3)
  • Apply: Identify, scope, and investigate problems and make complex logical deductions from evidence. (2.1)
  • Analyse: Discover, gather, and critically evaluate data and academic sources. (2.2)
  • Analyse: Organise and manage a major project using time management and collaborative skills. (3.2)
  • Synthesise: Develop advanced technical skills for effective and ethical contributions to society. (3.3)
  • Apply: Demonstrate well-developed individual and independent learning strategies enabled by peer review and self-reflection. (4.1)
  • Synthesise: Adapt critical thinking skills to develop creative solutions for contemporary medicinal chemistry problems. (4.3)
  • Apply: Demonstrate advanced speaking skills to communicate scientific discovery effectively to peers and other scientific audiences. (5.1)
  • Analyse: Exhibit high-quality writing skills to present a clear and coherent exposition of knowledge and ideas to a variety of audiences. (5.2)

Contribution to the development of graduate attributes

The subject will provide you with the knowledge and skills to prepare you to practice in a professional context.

Graduate Attribute 1 - Disciplinary knowledge:
You will apply understanding of your Honours research topic to produce a journal article in a specified style. You will also complete a series of prescribed learning activities due throughout the semester, using the discipline content and skills you will learn in the workshops.

Graduate attribute 2 - Research, inquiry and critical thinking:
You will investigate and solve problems by critically evaluating the literature.

Graduate Attribute 3 - Professional, Ethical and Social Responsibility:
You will learn to acquire, develop, employ and integrate a range of skills within a professional context, autonomously and collaboratively. You will also develop generic skills such time management, personal organisation and event organisation through teamwork. An awareness of the professional research space in which you will operate will also be developed. You will develop an understanding of how your chosen area of research underpins society and the application of it in a professional context. Critical discussions during workshops around complex, topical issues in science will be explored and assessed. This will involve you researching, identifying and engaging with current and future challenges affecting you as a professional.

Graduate Attribute 4 - Reflection, innovation and creativity:
You will use self-directed learning to discover new information and adapt critical thinking skills.

Graduate Attribute 5 – Communication:
You will develop written and oral communication skills through a series of informative workshops. The specific aspects of written communication developed are the ability to write a journal article using appropriate language and a specified format. Oral communication skills are also developed so you can deliver a formal presentation and to facilitate the organisation of a symposium with (and for) your peers.

Teaching and learning strategies

This subject involves a series of workshops and group activities aimed at developing discipline specific professional skills, communication skills, and organisational skills through active and self-directed learning.

You will be introduced to key professional skills required as a practicing chemist; including communication skills, professionalism and scientific writing. You will work collaboratively with your peers to organise a symposium for each of you to give presentations for which you will receive feedback from 2-3 panel members (for future use in your final Honours presentations). You will also provide an evaluation of your peer's presentations which will be critically assessed.

The prescribed workshops will help you develop the writing skills and knowledge to complete your literature review for your thesis and aid in your development of self-directed project and time management. Workshops will also provide you with information on the necessary skills and elements of a successful presentation, which you can then apply in your final presentation. You will also learn about career development strategies, and how these can be used to integrate yourself into a globally-situated workplace.

Content (topics)

  1. Introduction to research at UTS
  2. Literature review and writing skills
  3. Project/time management
  4. Advanced presentation skills
  5. Preparation of written work as a scientific journal article
  6. Patent database searching and evaluation
  7. Symmetry and group theory
  8. Symposium organisation and facilitation

Assessment

Assessment task 1: Written Assignment (journal article)

Intent:

This assessment task contributes to the development of the following graduate attributes;

1. Disciplinary knowledge

2. Research, inquiry and critical thinking

3. Professional, ethical and social responsibility

5. Communication

Objective(s):

This assessment task addresses subject learning objective(s):

2, 3 and 5

This assessment task contributes to the development of course intended learning outcome(s):

1.2, 2.1, 3.3 and 5.2

Type: Report
Groupwork: Individual
Weight: 25%
Criteria:

An assessment rubric will be available on UTSOnline.

For the written journal article, the criteria are;

  • Adhere to the ACS guidelines for presentation and formatting
  • Clarity of writing
  • Use of figuresand/or schemes and/or equations
  • Appropriate and sufficient referencing

Assessment task 2: Written Assignment (patent report)

Intent:

This assessment task contributes to the development of the following graduate attributes;

1. Disciplinary knowledge

2. Research, inquiry and critical thinking

3. Professional, ethical and social responsibility

4. Reflection, innovation and creativity

5. Communication

Objective(s):

This assessment task addresses subject learning objective(s):

1 and 3

This assessment task contributes to the development of course intended learning outcome(s):

1.2, 2.2, 3.3, 4.1, 4.3 and 5.2

Type: Report
Groupwork: Individual
Weight: 25%
Criteria:

An assessment rubric will be available on UTSOnline.

For the patent search report the criteria are;

  • cohesion in presenting an overview of the area and some scientific explanation
  • relevancy and appropriateness of selected patents
  • a comprehensive discussion of;
    • ?the efficacy of the claimed work
    • competition in the area
    • suggestion for directions to a hypothetical employer
  • presentation of report (use of figures etc.)

Assessment task 3: Written Assignment (symmetry and group theory)

Intent:

This assessment task contributes to the development of the following graduate attributes:

1. Disciplinary knowledge

2. Research, inquiry and critical thinking

4. Reflection, innovation and creativity

5. Communication

Objective(s):

This assessment task addresses subject learning objective(s):

3

This assessment task contributes to the development of course intended learning outcome(s):

1.2, 2.2, 4.3 and 5.2

Type: Exercises
Groupwork: Individual
Weight: 25%
Criteria:

Students will be assessed on their knowledge of and ability to explain (with worked answers) molecular group theory and the geometry of molecules. Students will be marked on the correctness of their answers, and provision of clear, structured worked answers.

Assessment task 4: Presentation and symposium organisation

Intent:

This assessment task contributes to the development of the following graduate attributes;

1. Disciplinary knowledge

2. Research, inquiry and critical thinking

3. Professional, ethical and social responsibility

4. Reflection, innovation and creativity

5. Communication

Objective(s):

This assessment task addresses subject learning objective(s):

2, 3 and 4

This assessment task contributes to the development of course intended learning outcome(s):

1.2, 1.3, 2.2, 3.2, 4.3 and 5.1

Type: Presentation
Groupwork: Group, group and individually assessed
Weight: 25%
Criteria:

An assessment rubric will be available on UTSOnline.

For the symposium, the criteria are;

  • Organisation skills
  • Event management skills
  • Professional conduct
  • Time-management skills

For the assessment of peer presentations, the criteria are;

  • Critical analysis of presentations

For the oral presentation, the criteria are;

  • Appropriate background information
  • Evidence of research skills
  • Interpretation of results
  • Understanding/ability to answer questions
  • Presentation skills