91709 Advanced Pharmacology6cp; Lectures (x5), Tutorials (x5) and Practicals (x2) (see Program)
Requisite(s): 91707 Fundamentals of Pharmacology
These requisites may not apply to students in certain courses. See access conditions.
This subject develops and extends the principles governing drug and xenobiotic action covered in 91707 Fundamentals of Pharmacology. It is designed to foster a problem-solving approach to pharmacology with particular emphasis on applying molecular pharmacology concepts to pathophysiological problems. The objectives are to further develop the concept of receptors as cellular determinants of drug and xenobiotic action, and to develop the concepts of modulated receptors and ion channels in determining drug action. Selective toxicity in the treatment of infections is examined as well as toxicokinetic factors, defense mechanisms, cellular reactivity, receptors and binding sites as determinants of target organ toxicity. The clinical efficacy of the major pharmacology drug classes used in the treatment of respiratory disease, cancer, affective and psychotic illnesses, cardiovascular disease, lipid disorders, blood disorders, diabetes, peptic ulcers, nausea and vomiting, are examined. Lectures are complemented by a tutorial program which emphasises the clinical nature of the subject and develops lecture material using a variety of tutorial and case study approaches.
Spring session, City campus
Detailed subject description.