University of Technology Sydney

65005 Strategies in Drug Synthesis

6cp; 6hpw: 3hpw (practical, on campus), 2hpw (lecture, online), 1hpw (tutorial, online)
Requisite(s): 65508 Organic Chemistry 2


The development of new drugs necessarily relies on the ability to design and synthesise new compounds. Strategies in drug synthesis is a fundamental component of medicinal chemistry; without it, the development of new drugs cannot progress from design to application, and ultimately to treatment. The subject tackles important factors in drug synthesis and examines and evaluates the strategies used to design feasible synthetic routes to bioactive molecules. Retrosynthetic analysis, disconnection approaches, pattern recognition and suitable methods for synthetic planning are discussed within the context of safety and feasibility. This subject builds on previous studies of organic reactions and spectroscopic techniques and applications of these concepts for organic synthesis. The subject explores a range of classical and modern organic reactions, including metal-catalysed reactions, asymmetric synthesis, and rearrangement in synthesis is presented. Literature searches in online databases such as SciFinder Scholar and Google Scholar and computer-aided molecular modelling are integrated as learning tools to allow students to develop their ability to design multi-step syntheses of complex organic molecules. Case studies on the design and synthesis of various bioactive molecules are explored to reiterate the importance of these strategies. When presented with a target molecule, students should be equipped with synthetic tools that enable them to develop a feasible synthetic scheme based on the firm idea and reliable reactions.

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